![](/images/graphics-bg.png)
Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model
Joint Authors
Salata, Luiz A.
Moharamzadeh, Keyvan
Hussain, Ibrahim
Brook, Ian M.
José de Oliveira Neto, Patrício
Source
International Journal of Dentistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model.
In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria.
One defect was left unfilled, one filled with collected autogenous bone, and the third defect was filled with the dentin-based bone substitute.
Following surgery and after a healing period of either 1 or 6 weeks, a CT scan was obtained.
Following sacrificing, the tissues were processed for histological examination.
The CT data showed the density in the area grafted with the dentin-based material was higher than the surrounding bone and the areas grafted with autologous bone after 1 week and 6 weeks of healing.
The area left unfilled remained an empty defect after 1 week and 6 weeks.
Histological examination of the defects filled with the dentin product after 6 weeks showed soft tissue encapsulation around the dentin particles.
It can be concluded that the rabbit calvarial model used in this study is a robust model for the assessment of bone materials.
Bovine dentin is a biostable material; however, it may not be suitable for repairing large 4-wall defects.
American Psychological Association (APA)
Hussain, Ibrahim& Moharamzadeh, Keyvan& Brook, Ian M.& José de Oliveira Neto, Patrício& Salata, Luiz A.. 2012. Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model. International Journal of Dentistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468834
Modern Language Association (MLA)
Hussain, Ibrahim…[et al.]. Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model. International Journal of Dentistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468834
American Medical Association (AMA)
Hussain, Ibrahim& Moharamzadeh, Keyvan& Brook, Ian M.& José de Oliveira Neto, Patrício& Salata, Luiz A.. Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model. International Journal of Dentistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468834