Tolerance-Inducing Strategies in Islet Transplantation
Joint Authors
Qian, Shiguang
Fung, John J.
Lu, Lina
Bhatt, Sumantha
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Allogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients.
Current use of immunosuppressive therapies for management of islet transplant recipients can be counterintuitive to islet function and can lead to complications in the long term.
The induction of donor-specific tolerance eliminates the dependency on immunosuppression and allows recipients to retain responses to foreign antigens.
The mechanisms by which tolerance is achieved involve the deletion of donor-reactive T cells, induction of T-cell anergy, immune deviation, and generation of regulatory T cells.
This review will outline the various methods used for inducing donor-specific tolerance in islet transplantation and will highlight the previously unforeseen potential of tissue stromal cells in promoting islet engraftment.
American Psychological Association (APA)
Bhatt, Sumantha& Fung, John J.& Lu, Lina& Qian, Shiguang. 2012. Tolerance-Inducing Strategies in Islet Transplantation. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468856
Modern Language Association (MLA)
Bhatt, Sumantha…[et al.]. Tolerance-Inducing Strategies in Islet Transplantation. International Journal of Endocrinology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-468856
American Medical Association (AMA)
Bhatt, Sumantha& Fung, John J.& Lu, Lina& Qian, Shiguang. Tolerance-Inducing Strategies in Islet Transplantation. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468856