Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction : Scavenging Free Heme to Preserve Vasculature Homeostasis
Joint Authors
Tolosano, Emanuela
Vinchi, Francesca
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Hemolysis results in the release of hemoglobin and heme into the bloodstream and is associated with the development of several pathologic conditions of different etiology, including hemoglobinopathies, hemolytic anemias, bacterial infections, malaria, and trauma.
In addition, hemolysis is associated with surgical procedures, hemodialysis, blood transfusion, and other conditions in which mechanical forces can lead to red blood cell rupture.
Free plasma hemoglobin and heme are toxic for the vascular endothelium since heme iron promotes oxidative stress that causes endothelial activation responsible for vasoocclusive events and thrombus formation.
Moreover, free hemoglobin scavenges nitric oxide, reducing its bioavailability, and heme favours ROS production, thus causing oxidative nitric oxide consumption.
This results in the dysregulation of the endothelium vasodilator:vasoconstrictor balance, leading to severe vasoconstriction and hypertension.
Thus, endothelial dysfunction and impairment of cardiovascular function represent a common feature of pathologic conditions associated with hemolysis.
In this review, we discuss how hemoglobin/heme released following hemolysis may affect vascular function and summarise the therapeutic approaches available to limit hemolysis-driven endothelial dysfunction.
Particular emphasis is put on recent data showing the beneficial effects obtained through the use of the plasma heme scavenger hemopexin in counteracting heme-mediated endothelial damage in mouse models of hemolytic diseases.
American Psychological Association (APA)
Vinchi, Francesca& Tolosano, Emanuela. 2013. Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction : Scavenging Free Heme to Preserve Vasculature Homeostasis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-468857
Modern Language Association (MLA)
Vinchi, Francesca& Tolosano, Emanuela. Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction : Scavenging Free Heme to Preserve Vasculature Homeostasis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-468857
American Medical Association (AMA)
Vinchi, Francesca& Tolosano, Emanuela. Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction : Scavenging Free Heme to Preserve Vasculature Homeostasis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-468857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468857