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Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin
Joint Authors
Mukherjee, Tapan K.
Malik, Parth
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Phenolic compounds have been very well known for their antioxidant properties, owing to their unique ability to act as free radical scavengers which, in turn, is an outstanding attribute of their unique biochemical structure.
Recent accumulating lines of evidence inculcate sustainable interest and curiosity towards the chemoprotective nature of the natural polyphenolic compound curcumin (diferuloylmethane) against oxidative stress-mediated disorders.
Curcumin is naturally found as a constituent of dietary spices called turmeric, extracted from the plant Curcuma longa.
However, like every phenolic antioxidant, curcumin possesses a concentration and medium dependent anti- and pro-oxidant behaviour.
A detailed study of the structure-function analysis and the understanding of the mode of action of curcumin as well as its chemical analogues is thus essential to understand the selective biochemical consequences of curcumin.
Moreover, the presence of transition metal ions, route of administration, and localized tissue are also the vital decisive factors to determine curcumin behaviour.
With this viewpoint, this paper sheds lights on the medium dependent prooxidative and antioxidative attributes of curcumin.
Further, with respect to emergence of nanocarriers, a brief discussion focusing on the biochemical effect exertion of curcumin chiefly due to targeted and slow release has also been added towards the end.
American Psychological Association (APA)
Malik, Parth& Mukherjee, Tapan K.. 2014. Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin. Chinese Journal of Biology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468865
Modern Language Association (MLA)
Malik, Parth& Mukherjee, Tapan K.. Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin. Chinese Journal of Biology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-468865
American Medical Association (AMA)
Malik, Parth& Mukherjee, Tapan K.. Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin. Chinese Journal of Biology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468865