Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population
Joint Authors
Du, Hongwu
Yang, Ze
Huang, Zezhi
Lv, Zeping
Zhang, Yan
Hu, Caiyou
Zheng, Chenguang
Lin, Jie
Sun, Liang
Shi, Xiaohong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human longevity is always a biological hotspot and so much effort has been devoted to identifying genes and genetic variations associated with longer lives.
Most of the demographic studies have highlighted that females have a longer life span than males.
The reasons for this are not entirely clear.
In this study, we carried out a pool-based, epigenome-wide investigation of DNA methylation profiles in male and female nonagenarians/centenarians using the Illumina 450 K Methylation Beadchip assays.
Although no significant difference was detected for the average methylation levels of examined CpGs (or probes) between male and female samples, a significant number of differentially methylated probes (DMPs) were identified, which appeared to be enriched in certain chromosome regions and certain parts of genes.
Further analysis of DMP-containing genes (named DMGs) revealed that almost all of them are solely hypermethylated or hypomethylated.
Functional enrichment analysis of these DMGs indicated that DNA hypermethylation and hypomethylation may regulate genes involved in different biological processes, such as hormone regulation, neuron projection, and disease-related pathways.
This is the first effort to explore the gender-based methylome difference in nonagenarians/centenarians, which may provide new insights into the complex mechanism of longevity gender gap of human beings.
American Psychological Association (APA)
Sun, Liang& Lin, Jie& Du, Hongwu& Hu, Caiyou& Huang, Zezhi& Lv, Zeping…[et al.]. 2014. Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-468867
Modern Language Association (MLA)
Sun, Liang…[et al.]. Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-468867
American Medical Association (AMA)
Sun, Liang& Lin, Jie& Du, Hongwu& Hu, Caiyou& Huang, Zezhi& Lv, Zeping…[et al.]. Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-468867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468867