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Molecular Docking Assessment of Efficacy of Different Clinically Used Arsenic Chelator Drugs
Joint Authors
Majumder, Durjoy
Mukherjee, Sayan
Source
Journal of Computational Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arsenic contamination of ground water has become a global problem affecting specially, south-east Asian countries like Bangladesh and eastern parts of India.
It also affects South America and some parts of the US.
Different organs of the physiological system are affected due to contamination of inorganic arsenic in water.
Animal studies with different chelators are not very conclusive as far as the multi/differential organ effect(s) of arsenic is concerned.
Our docking study establishes the molecular rationale of blood test for early detection of arsenic toxicity; as arsenic has a high affinity to albumin, a plasma protein and actin, a structural protein of all cells including Red Blood Cells.
This study also shows that there is a little possibility of male reproductive organs toxicity by different forms of inorganic arsenic; however, female reproductive system is very much susceptible to sodium-arsenite.
Through comparative analysis regarding the chelating effectiveness among the available arsenic chelator drugs, meso-2,3 dimercaptosuccinic acid (DMSA) and in some cases lipoic acid is the most preferred choice of drug for removing of arsenic deposits.
This computational method actually reinforces the clinical finding regarding DMSA as the most preferred drug in removal of arsenic deposits from majority of the human tissues.
American Psychological Association (APA)
Majumder, Durjoy& Mukherjee, Sayan. 2013. Molecular Docking Assessment of Efficacy of Different Clinically Used Arsenic Chelator Drugs. Journal of Computational Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468871
Modern Language Association (MLA)
Majumder, Durjoy& Mukherjee, Sayan. Molecular Docking Assessment of Efficacy of Different Clinically Used Arsenic Chelator Drugs. Journal of Computational Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-468871
American Medical Association (AMA)
Majumder, Durjoy& Mukherjee, Sayan. Molecular Docking Assessment of Efficacy of Different Clinically Used Arsenic Chelator Drugs. Journal of Computational Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468871