MHC I Stabilizing Potential of Computer-Designed Octapeptides
Joint Authors
Wiesmüller, Karl-Heinz
Freier, Anja
Walden, Peter
Wisniewska, Joanna M.
Schneider, Gisbert
Hiss, Jan A.
Wrede, Paul
Jäger, Natalie
Losch, Florian O.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Experimental results are presented for 180 in silico designed octapeptide sequences and their stabilizing effects on the major histocompatibility class I molecule H-2Kb.
Peptide sequence design was accomplished by a combination of an ant colony optimization algorithm with artificial neural network classifiers.
Experimental tests yielded nine H-2Kb stabilizing and 171 nonstabilizing peptides.
28 among the nonstabilizing octapeptides contain canonical motif residues known to be favorable for MHC I stabilization.
For characterization of the area covered by stabilizing and non-stabilizing octapeptides in sequence space, we visualized the distribution of 100,603 octapeptides using a self-organizing map.
The experimental results present evidence that the canonical sequence motives of the SYFPEITHI database on their own are insufficient for predicting MHC I protein stabilization.
American Psychological Association (APA)
Wisniewska, Joanna M.& Jäger, Natalie& Freier, Anja& Losch, Florian O.& Wiesmüller, Karl-Heinz& Walden, Peter…[et al.]. 2010. MHC I Stabilizing Potential of Computer-Designed Octapeptides. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-468880
Modern Language Association (MLA)
Wisniewska, Joanna M.…[et al.]. MHC I Stabilizing Potential of Computer-Designed Octapeptides. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-468880
American Medical Association (AMA)
Wisniewska, Joanna M.& Jäger, Natalie& Freier, Anja& Losch, Florian O.& Wiesmüller, Karl-Heinz& Walden, Peter…[et al.]. MHC I Stabilizing Potential of Computer-Designed Octapeptides. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-468880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468880