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Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly
Joint Authors
Hall, James R.
Johnson, Leigh A.
O'Bryant, S. E.
Barber, Robert C.
Source
Depression Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Determine the relationship between depressive symptom clusters and neuropsychological test performance in an elderly cohort of cognitively normal controls and mild Alzheimer's disease (AD).
Design.
Cross-sectional analysis.
Setting.
Four health science centers in Texas.
Participants.
628 elderly individuals (272 diagnosed with mild AD and 356 controls) from ongoing longitudinal study of Alzheimer's disease.
Measurements.
Standard battery of neuropsychological tests and the 30-item Geriatric Depression Scale with regressions model generated on GDS-30 subscale scores (dysphoria, apathy, meaninglessness and cognitive impairment) as predictors and neuropsychological tests as outcome variables.
Follow-up analyses by gender were conducted.
Results.
For AD, all symptom clusters were related to specific neurocognitive domains; among controls apathy and cognitive impairment were significantly related to neuropsychological functioning.
The relationship between performance and symptom clusters was significantly different for males and females in each group.
Conclusion.
Findings suggest the need to examine disease status and gender when considering the impact of depressive symptoms on cognition.
American Psychological Association (APA)
Hall, James R.& O'Bryant, S. E.& Johnson, Leigh A.& Barber, Robert C.. 2011. Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly. Depression Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-468889
Modern Language Association (MLA)
Hall, James R.…[et al.]. Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly. Depression Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-468889
American Medical Association (AMA)
Hall, James R.& O'Bryant, S. E.& Johnson, Leigh A.& Barber, Robert C.. Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly. Depression Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-468889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468889