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Tuberous Sclerosis Associated with Polycystic Kidney Disease : Effects of Rapamycin after Renal Transplantation
Joint Authors
Vázquez-Sánchez, F.
Rosado, C.
Fraile, P.
García-Cosmes, P.
Source
Case Reports in Transplantation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Tuberous sclerosis is rarely associated with autosomal dominant polycystic kidney disease in the so-called tuberous sclerosis complex.
This association leads to an increased frequency of end-stage renal disease.
We present a patient suffering from both syndromes, who received a renal graft and anticalcineurinic drugs as immunosuppressive agents.
Progressive titration of the drug was necessary in order to attain the effective doses due to the enzymatic induction caused by concomitant treatment with antiepileptic drugs.
These high doses resulted in nephrotoxicity.
Immunosuppressor treatment was switched to rapamycin, whereby an improvement in renal function and other signs of tuberous sclerosis and polycystic kidney disease was observed.
This case report highlights both the efficacy and safety of rapamycin as an immunosuppressor treatment and its capacity for controlling other symptoms of these genetic-related disorders.
American Psychological Association (APA)
Rosado, C.& García-Cosmes, P.& Fraile, P.& Vázquez-Sánchez, F.. 2013. Tuberous Sclerosis Associated with Polycystic Kidney Disease : Effects of Rapamycin after Renal Transplantation. Case Reports in Transplantation،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-468903
Modern Language Association (MLA)
Rosado, C.…[et al.]. Tuberous Sclerosis Associated with Polycystic Kidney Disease : Effects of Rapamycin after Renal Transplantation. Case Reports in Transplantation No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-468903
American Medical Association (AMA)
Rosado, C.& García-Cosmes, P.& Fraile, P.& Vázquez-Sánchez, F.. Tuberous Sclerosis Associated with Polycystic Kidney Disease : Effects of Rapamycin after Renal Transplantation. Case Reports in Transplantation. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-468903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468903