The Human Plasma Membrane Peripherome : Visualization and Analysis of Interactions
Joint Authors
Nastou, Katerina C.
Kremizas, Kimon E.
Tsaousis, Georgios N.
Litou, Zoi I.
Hamodrakas, Stavros J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A major part of membrane function is conducted by proteins, both integral and peripheral.
Peripheral membrane proteins temporarily adhere to biological membranes, either to the lipid bilayer or to integral membrane proteins with noncovalent interactions.
The aim of this study was to construct and analyze the interactions of the human plasma membrane peripheral proteins (peripherome hereinafter).
For this purpose, we collected a dataset of peripheral proteins of the human plasma membrane.
We also collected a dataset of experimentally verified interactions for these proteins.
The interaction network created from this dataset has been visualized using Cytoscape.
We grouped the proteins based on their subcellular location and clustered them using the MCL algorithm in order to detect functional modules.
Moreover, functional and graph theory based analyses have been performed to assess biological features of the network.
Interaction data with drug molecules show that ~10% of peripheral membrane proteins are targets for approved drugs, suggesting their potential implications in disease.
In conclusion, we reveal novel features and properties regarding the protein-protein interaction network created by peripheral proteins of the human plasma membrane.
American Psychological Association (APA)
Nastou, Katerina C.& Tsaousis, Georgios N.& Kremizas, Kimon E.& Litou, Zoi I.& Hamodrakas, Stavros J.. 2014. The Human Plasma Membrane Peripherome : Visualization and Analysis of Interactions. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-468909
Modern Language Association (MLA)
Nastou, Katerina C.…[et al.]. The Human Plasma Membrane Peripherome : Visualization and Analysis of Interactions. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-468909
American Medical Association (AMA)
Nastou, Katerina C.& Tsaousis, Georgios N.& Kremizas, Kimon E.& Litou, Zoi I.& Hamodrakas, Stavros J.. The Human Plasma Membrane Peripherome : Visualization and Analysis of Interactions. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-468909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468909