Immunotherapy Using Dendritic Cells against Multiple Myeloma : How to Improve?
Joint Authors
Nguyen-Pham, Thanh-Nhan
Lee, Je-Jung
Kim, Hyeoung-Joon
Lee, Yoon-Kyung
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Multiple myeloma (MM) is a good target disease in which one can apply cellular immunotherapy, which is based on the graft-versus-myeloma effect.
This role of immune effector cells provides the framework for the development of immune-based therapeutic options that use antigen-presenting cells (APCs) with increased potency, such as dendritic cells (DCs), in MM.
Current isolated idiotype (Id), myeloma cell lysates, myeloma dying cells, DC-myeloma hybrids, or DC transfected with tumor-derived RNA has been used for immunotherapy with DCs.
Immunological inhibitory cytokines, such as TGF-β, IL-10, IL-6 and VEGF, which are produced from myeloma cells, can modulate antitumor host immune response, including the abrogation of DC function, by constitutive activation of STAT3.
Therefore, even the immune responses have been observed in clinical trials, the clinical response was rarely improved following DC vaccinations in MM patients.
We are going to discuss how to improve the efficacy of DC vaccination in MM.
American Psychological Association (APA)
Nguyen-Pham, Thanh-Nhan& Lee, Yoon-Kyung& Kim, Hyeoung-Joon& Lee, Je-Jung. 2012. Immunotherapy Using Dendritic Cells against Multiple Myeloma : How to Improve?. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468950
Modern Language Association (MLA)
Nguyen-Pham, Thanh-Nhan…[et al.]. Immunotherapy Using Dendritic Cells against Multiple Myeloma : How to Improve?. Clinical and Developmental Immunology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-468950
American Medical Association (AMA)
Nguyen-Pham, Thanh-Nhan& Lee, Yoon-Kyung& Kim, Hyeoung-Joon& Lee, Je-Jung. Immunotherapy Using Dendritic Cells against Multiple Myeloma : How to Improve?. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468950