A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus
Joint Authors
Bhagwat, Nikhil
Chadha, Manoj
Joshi, Ameya
Varthakavi, Premlata
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk.
86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study.
After history and examination, BMD and body composition were assessed by dual energy X-ray absorptiometry (DXA).
Serum samples were analyzed for calcium, phosphorus, albumin, creatinine, alkaline phosphatase, 25 (OH) vitamin D3, intact parathormone (PTH) levels (both cases and controls) and HbA1c, antimicrosomal and IgA tissue transglutaminase (IgA TTG) antibodies, cortisol, follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP3) (cases only).
T1DM cases had a lower BMD as compared to controls at both total body (TB) and lumbar spine (LS) (P<0.05).
Patients with celiac autoimmunity (CA) had significantly, lower BMD as compared to age, sex, and body mass index (BMI) matched T1DM controls.
Linear regression analysis showed that low BMD in T1DM patients was associated with poor glycaemic control, lower IGF-1 levels, less physical activity (in total population as well as in male and female subgroups), and lower body fat percentage (in females) and higher alkaline phosphatase level (in males) (P<0.05).
American Psychological Association (APA)
Joshi, Ameya& Varthakavi, Premlata& Chadha, Manoj& Bhagwat, Nikhil. 2013. A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus. Journal of Osteoporosis،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468960
Modern Language Association (MLA)
Joshi, Ameya…[et al.]. A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus. Journal of Osteoporosis No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-468960
American Medical Association (AMA)
Joshi, Ameya& Varthakavi, Premlata& Chadha, Manoj& Bhagwat, Nikhil. A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus. Journal of Osteoporosis. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468960