Study of the Association between ITPKC Genetic Polymorphisms and Calcium Nephrolithiasis
Joint Authors
Kan, Wei-Chih
Hsu, Wenli
Hsu, Yu-Wen
Lu, Hsing-Fang
Chang, Wei Chiao
Chiu, Siou-Jin
Chou, Yii-Her
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Nephrolithiasis is a multifactorial disease caused by environmental, hormonal, and genetic factors.
Genetic polymorphisms of ORAI1, which codes for the main subunit of the store-operated calcium (SOC) channel, were reported to be associated with the risk and recurrence of calcium nephrolithiasis.
Inositol 1,4,5-trisphosphate (IP3) 3-kinase C (ITPKC) is a negative regulator of the SOC channel-mediated signaling pathway.
We investigated the association between calcium containing nephrolithiasis and genetic variants of ITPKC gene in Taiwanese patients.
365 patients were recruited in this study.
Eight tagging single nucleotide polymorphisms of ITPKC were selected for genotyping.
ITPKC genotypes were determined by TaqMan assay.
ITPKC plasmids were transfected into cells to evaluate the intracellular calcium mobilization.
Our results indicated that rs2607420 CC genotype in the intron region of the ITPKC gene is associated with a lower eGFR by both Modification of Diet in Renal Diseases (P=0.0405) and Cockcroft-Gault (P=0.0215) equations in patients with calcium nephrolithiasis.
Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling.
American Psychological Association (APA)
Kan, Wei-Chih& Chou, Yii-Her& Chiu, Siou-Jin& Hsu, Yu-Wen& Lu, Hsing-Fang& Hsu, Wenli…[et al.]. 2014. Study of the Association between ITPKC Genetic Polymorphisms and Calcium Nephrolithiasis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-468962
Modern Language Association (MLA)
Kan, Wei-Chih…[et al.]. Study of the Association between ITPKC Genetic Polymorphisms and Calcium Nephrolithiasis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-468962
American Medical Association (AMA)
Kan, Wei-Chih& Chou, Yii-Her& Chiu, Siou-Jin& Hsu, Yu-Wen& Lu, Hsing-Fang& Hsu, Wenli…[et al.]. Study of the Association between ITPKC Genetic Polymorphisms and Calcium Nephrolithiasis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-468962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468962