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ELFN1-AS1 : A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors
Joint Authors
Polev, Dmitrii E.
Krukovskaya, Larisa L.
Kozlov, Andrei P.
Karnaukhova, Iuliia K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human gene LOC100505644 uncharacterized LOC100505644 [Homo sapiens] (Entrez Gene ID 100505644) is abundantly expressed in tumors but weakly expressed in few normal tissues.
Till now the function of this gene remains unknown.
Here we identified the chromosomal borders of the transcribed region and the major splice form of the LOC100505644-specific transcript.
We characterised the major regulatory motifs of the gene and its splice sites.
Analysis of the secondary structure of the major transcript variant revealed a hairpin-like structure characteristic for precursor microRNAs.
Comparative genomic analysis of the locus showed that it originated in primates de novo.
Taken together, our data indicate that human gene LOC100505644 encodes some non-protein coding RNA, likely a microRNA.
It was assigned a gene symbol ELFN1-AS1 (ELFN1 antisense RNA 1 (non-protein coding)).
This gene combines features of evolutionary novelty and predominant expression in tumors.
American Psychological Association (APA)
Polev, Dmitrii E.& Karnaukhova, Iuliia K.& Krukovskaya, Larisa L.& Kozlov, Andrei P.. 2014. ELFN1-AS1 : A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468983
Modern Language Association (MLA)
Polev, Dmitrii E.…[et al.]. ELFN1-AS1 : A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-468983
American Medical Association (AMA)
Polev, Dmitrii E.& Karnaukhova, Iuliia K.& Krukovskaya, Larisa L.& Kozlov, Andrei P.. ELFN1-AS1 : A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-468983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468983