Histological and Immunohistochemical Revision of Hepatocellular Adenomas : A Learning Experience
Joint Authors
Fonseca, S.
Jouret-Mourin, A.
Reding, R.
Rahier, J.
Annet, L.
Godecharles, S.
Hubert, C.
Otte, J. B.
Gigot, J. F.
Sempoux, Christine
Hoton, D.
Dardenne, S.
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1α-inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β-catenin-activated HCA (b-HCA).
We reviewed retrospectively our surgical HCA series to learn how to recognize the different subtypes histopathologically and how to interpret adequately their immunohistochemical staining.
From January 1992 to January 2012, 37 patients underwent surgical resection for HCA in our institution.
Nine had H-HCA (25%) characterized by steatosis and loss of L-FABP expression; 20 had IHCA (55.5%) showing CRP and/or SAA expression, sinusoidal dilatation, and variable inflammation; and 1 patient had both H-HCA and IHCA.
In 5 patients (14%), b-HCA with GS and β-catenin nuclear positivity was diagnosed, two already with hepatocellular carcinoma.
Two cases (5.5%) remained unclassified.
One of the b-HCA showed also the H-HCA histological and immunohistochemical characteristics suggesting a subgroup of β-catenin-activated/HNF1α-inactivated HCA, another b-HCA exhibited the IHCA histological and immunohistochemical characteristics suggesting a subgroup of β-catenin-activated/inflammatory HCA.
Interestingly, three patients had underlying vascular abnormalities.
Using the recently published criteria enabled us to classify histopathologically our retrospective HCA surgical series with accurate recognition of b-HCA for which we confirm the higher risk of malignant transformation.
We also underlined the association between HCA and vascular abnormalities.
American Psychological Association (APA)
Fonseca, S.& Hoton, D.& Dardenne, S.& Annet, L.& Hubert, C.& Godecharles, S.…[et al.]. 2013. Histological and Immunohistochemical Revision of Hepatocellular Adenomas : A Learning Experience. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469004
Modern Language Association (MLA)
Fonseca, S.…[et al.]. Histological and Immunohistochemical Revision of Hepatocellular Adenomas : A Learning Experience. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469004
American Medical Association (AMA)
Fonseca, S.& Hoton, D.& Dardenne, S.& Annet, L.& Hubert, C.& Godecharles, S.…[et al.]. Histological and Immunohistochemical Revision of Hepatocellular Adenomas : A Learning Experience. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469004