Lipoprotein Lipase as a Candidate Target for Cancer PreventionTherapy
Joint Authors
Mutoh, Michihiro
Takahashi, Mami
Takasu, Shinji
Nakagama, Hitoshi
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Epidemiological studies have shown that serum triglyceride (TG) levels are linked with risk of development of cancer, including colorectal and pancreatic cancers, and their precancerous lesions.
Thus, it is assumed that serum TG plays an important role in carcinogenesis, and the key enzyme lipoprotein lipase (LPL), which catalyzes the hydrolysis of plasma TG, may therefore be involved.
Dysregulation of LPL has been reported to contribute to many human diseases, such as atherosclerosis, chylomicronaemia, obesity, and type 2 diabetes.
Recently, it has been reported that LPL gene deficiency, such as due to chromosome 8p22 loss, LPL gene polymorphism, and epigenetic changes in its promoter region gene, increases cancer risk, especially in the prostate.
In animal experiments, high serum TG levels seem to promote sporadic/carcinogen-induced genesis of colorectal and pancreatic cancers.
Interestingly, tumor suppressive effects of LPL inducers, such as PPAR ligands, NO-1886, and indomethacin, have been demonstrated in animal models.
Moreover, recent evidence that LPL plays important roles in inflammation and obesity implies that it is an appropriate general target for chemopreventive and chemotherapeutic agents.
American Psychological Association (APA)
Takasu, Shinji& Mutoh, Michihiro& Takahashi, Mami& Nakagama, Hitoshi. 2011. Lipoprotein Lipase as a Candidate Target for Cancer PreventionTherapy. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469047
Modern Language Association (MLA)
Takasu, Shinji…[et al.]. Lipoprotein Lipase as a Candidate Target for Cancer PreventionTherapy. Biochemistry Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-469047
American Medical Association (AMA)
Takasu, Shinji& Mutoh, Michihiro& Takahashi, Mami& Nakagama, Hitoshi. Lipoprotein Lipase as a Candidate Target for Cancer PreventionTherapy. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469047