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Determinants for Substrate Specificity of Protein Phosphatase 2A
Joint Authors
Merrill, Ronald A.
Strack, Stefan
Slupe, Andrew M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function.
PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B).
Substrate specificity of the holoenzyme complex is determined by the subcellular locale the complex is confined to, selective incorporation of the B subunit, interactions with endogenous inhibitory proteins, and specific intermolecular interactions between PP2A and target substrates.
Here, we discuss recent studies that have advanced our understanding of the molecular determinants for PP2A substrate specificity.
American Psychological Association (APA)
Slupe, Andrew M.& Merrill, Ronald A.& Strack, Stefan. 2011. Determinants for Substrate Specificity of Protein Phosphatase 2A. Enzyme Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469054
Modern Language Association (MLA)
Slupe, Andrew M.…[et al.]. Determinants for Substrate Specificity of Protein Phosphatase 2A. Enzyme Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-469054
American Medical Association (AMA)
Slupe, Andrew M.& Merrill, Ronald A.& Strack, Stefan. Determinants for Substrate Specificity of Protein Phosphatase 2A. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469054