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The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases
Joint Authors
Saba, Reuben
Patterson, Aileen P.
Booth, Stephanie A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The detection and subsequent quantification of photons emitted from living tissues, using highly sensitive charged-couple device (CCD) cameras, have enabled investigators to noninvasively examine the intricate dynamics of molecular reactions in wide assortment of experimental animals under basal and pathophysiological conditions.
Nevertheless, extrapolation of this in vivo optical imaging technology to the study of the mammalian brain and related neurodegenerative conditions is still in its infancy.
In this review, we introduce the reader to the emerging use of in vivo optical imaging in the study of neurodegenerative diseases.
We highlight the current instrumentation that is available and reporter molecules (fluorescent and bioluminescent) that are commonly used.
Moreover, we examine how in vivo optical imaging using transgenic reporter mice has provided new insights into Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Prion disease, and neuronal damage arising from excitotoxicity and inflammation.
Furthermore, we also touch upon studies that have utilized these technologies for the development of therapeutic strategies for neurodegenerative conditions that afflict humans.
American Psychological Association (APA)
Patterson, Aileen P.& Booth, Stephanie A.& Saba, Reuben. 2014. The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-469083
Modern Language Association (MLA)
Patterson, Aileen P.…[et al.]. The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-469083
American Medical Association (AMA)
Patterson, Aileen P.& Booth, Stephanie A.& Saba, Reuben. The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-469083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469083