Odanacatib, a New Drug for the Treatment of Osteoporosis : Review of the Results in Postmenopausal Women
Joint Authors
Pinacho, Florentino
Lopez-Menendez, María
Dueňas Laita, Antonio
de Luis, Daniel
Pérez-Castrillón, José Luis
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Osteoclasts are specialized cells that initiate the process of bone resorption, which has two phases, dissolution of the mineral component and degradation of the organic matrix, in which cathepsin K plays a key role.
Cathepsin K inhibitors, which block the activity of cathepsin on bone resorption lacunae, may be a new therapeutic option in osteoporosis.
Odanacatib is a nonpeptidic biaryl inhibitor of cathepsin K.
Two studies have evaluated the efficacy and safety of odanacatib, a phase I study to determine the dose and a phase II study of safety and efficacy.
Due to the long half-life of odanacatib and the similar effects of different doses on bone remodeling markers, a weekly dosage was chosen for the phase II trail, with the best results being obtained with a dose of 50 mg.
At 36 months, increases in bone mineral density similar to those produced by other powerful antiresorptive drugs (zoledronate and denosumab) were observed but there were differences in the behaviour of bone remodeling markers.
Data on fractures from the phase III trial currently in development are required to confirm these possible advantages.
American Psychological Association (APA)
Pérez-Castrillón, José Luis& Pinacho, Florentino& de Luis, Daniel& Lopez-Menendez, María& Dueňas Laita, Antonio. 2010. Odanacatib, a New Drug for the Treatment of Osteoporosis : Review of the Results in Postmenopausal Women. Journal of Osteoporosis،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-469111
Modern Language Association (MLA)
Pérez-Castrillón, José Luis…[et al.]. Odanacatib, a New Drug for the Treatment of Osteoporosis : Review of the Results in Postmenopausal Women. Journal of Osteoporosis No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-469111
American Medical Association (AMA)
Pérez-Castrillón, José Luis& Pinacho, Florentino& de Luis, Daniel& Lopez-Menendez, María& Dueňas Laita, Antonio. Odanacatib, a New Drug for the Treatment of Osteoporosis : Review of the Results in Postmenopausal Women. Journal of Osteoporosis. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-469111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469111