The Role of GLUK5-Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations
Joint Authors
Jane, David E.
Cunningham, Mark O.
Stanger, Heather L.
Alford, Rebekah
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Using in vitro brain slices of hippocampus and cortex, neuronal oscillations in the frequency range of 30–80 Hz (gamma frequency oscillations) can be induced by a number of pharmacological manipulations.
The most routinely used is the bath application of the broad-spectrum glutamate receptor agonist, kainic acid.
In the hippocampus, work using transgenic kainate receptor knockout mice have revealed information about the specific subunit composition of the kainate receptor implicated in the generation and maintenance of the gamma frequency oscillation.
However, there is a paucity of such detail regarding gamma frequency oscillation in the cortex.
Using specific pharmacological agonists and antagonists for the kainate receptor, we have set out to examine the contribution of kainate receptor subtypes to gamma frequency oscillation in the entorhinal cortex.
The findings presented demonstrate that in contrast to the hippocampus, kainate receptors containing the GLUK5 subunit are critically important for the generation and maintenance of gamma frequency oscillation in the entorhinal cortex.
Future work will concentrate on determining the exact nature of the cellular expression of kainate receptors in the entorhinal cortex.
American Psychological Association (APA)
Stanger, Heather L.& Alford, Rebekah& Jane, David E.& Cunningham, Mark O.. 2008. The Role of GLUK5-Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations. Neural Plasticity،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-469121
Modern Language Association (MLA)
Stanger, Heather L.…[et al.]. The Role of GLUK5-Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations. Neural Plasticity No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-469121
American Medical Association (AMA)
Stanger, Heather L.& Alford, Rebekah& Jane, David E.& Cunningham, Mark O.. The Role of GLUK5-Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-469121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469121