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Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy
Joint Authors
Manucha, Walter
Mazzei, Luciana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context.
The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development.
Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure.
Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis.
Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction.
Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular, and functional experiments as proposed in our and other research labs allows us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.
American Psychological Association (APA)
Mazzei, Luciana& Manucha, Walter. 2013. Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy. Advances in Urology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-469134
Modern Language Association (MLA)
Mazzei, Luciana& Manucha, Walter. Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy. Advances in Urology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-469134
American Medical Association (AMA)
Mazzei, Luciana& Manucha, Walter. Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-469134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469134