The Continuing Evolution of HIV-1 Therapy : Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets
Joint Authors
Buckheit, Robert W.
Hartman, Tracy L.
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
During the past three decades, over thirty-five anti-HIV-1 therapies have been developed for use in humans and the progression from monotherapeutic treatment regimens to today’s highly active combination antiretroviral therapies has had a dramatic impact on disease progression in HIV-1-infected individuals.
In spite of the success of AIDS therapies and the existence of inhibitors of HIV-1 reverse transcriptase, protease, entry and fusion, and integrase, HIV-1 therapies still have a variety of problems which require continued development efforts to improve efficacy and reduce toxicity, while making drugs that can be used throughout both the developed and developing world, in pediatric populations, and in pregnant women.
Highly active antiretroviral therapies (HAARTs) have significantly delayed the progression to AIDS, and in the developed world HIV-1-infected individuals might be expected to live normal life spans while on lifelong therapies.
However, the difficult treatment regimens, the presence of class-specific drug toxicities, and the emergence of drug-resistant virus isolates highlight the fact that improvements in our therapeutic regimens and the identification of new and novel viral and cellular targets for therapy are still necessary.
Antiretroviral therapeutic strategies and targets continue to be explored, and the development of increasingly potent molecules within existing classes of drugs and the development of novel strategies are ongoing.
American Psychological Association (APA)
Hartman, Tracy L.& Buckheit, Robert W.. 2012. The Continuing Evolution of HIV-1 Therapy : Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets. Molecular Biology International،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-469155
Modern Language Association (MLA)
Hartman, Tracy L.& Buckheit, Robert W.. The Continuing Evolution of HIV-1 Therapy : Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets. Molecular Biology International No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-469155
American Medical Association (AMA)
Hartman, Tracy L.& Buckheit, Robert W.. The Continuing Evolution of HIV-1 Therapy : Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-469155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469155