![](/images/graphics-bg.png)
Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Joint Authors
Fernández-Alfonso, Maria S.
Ruiz-Gayo, Mariano
Aranguez, Isabel
Somoza, Beatriz
Gil-Ortega, Marta
García-Prieto, Concha F.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Most blood vessels are surrounded by adipose tissue.
Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies.
In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta.
Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified.
PVAT undergoes structural and functional changes in obesity.
During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function.
However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease.
The aim of this review is to focus on PVAT dysfunction mechanisms in obesity.
American Psychological Association (APA)
Fernández-Alfonso, Maria S.& Gil-Ortega, Marta& García-Prieto, Concha F.& Aranguez, Isabel& Ruiz-Gayo, Mariano& Somoza, Beatriz. 2013. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469164
Modern Language Association (MLA)
Fernández-Alfonso, Maria S.…[et al.]. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity. International Journal of Endocrinology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469164
American Medical Association (AMA)
Fernández-Alfonso, Maria S.& Gil-Ortega, Marta& García-Prieto, Concha F.& Aranguez, Isabel& Ruiz-Gayo, Mariano& Somoza, Beatriz. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469164