The Dual Role of Zonula Occludens (ZO) Proteins
Joint Authors
Steinbacher, P.
Zweimueller-Mayer, J.
Bauer, H. C.
Lametschwandtner, A.
Bauer, H.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions.
In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton.
ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity.
Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation.
Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence.
Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus.
Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open.
This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior.
American Psychological Association (APA)
Bauer, H.& Zweimueller-Mayer, J.& Steinbacher, P.& Lametschwandtner, A.& Bauer, H. C.. 2010. The Dual Role of Zonula Occludens (ZO) Proteins. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-469215
Modern Language Association (MLA)
Bauer, H.…[et al.]. The Dual Role of Zonula Occludens (ZO) Proteins. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-469215
American Medical Association (AMA)
Bauer, H.& Zweimueller-Mayer, J.& Steinbacher, P.& Lametschwandtner, A.& Bauer, H. C.. The Dual Role of Zonula Occludens (ZO) Proteins. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-469215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469215