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Molecular Evolution of the Vertebrate FK506 Binding Protein 25
Joint Authors
Li, Hao
Gong, Xiao-Jian
Wang, Yong-Qing
Wei, Xiao-Long
Wei, Ji-Fu
Liu, Fei
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity.
FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating transcription and chromatin structure.
The calculation of nonsynonymous and synonymous substitution rates suggested that FKBP25 undergoes purifying selection throughout the whole vertebrate evolution.
Moreover, the result of site-specific tests showed that no sites were detected under positive selection.
Only one PPIase domain was detected by searching FKBP25 sequences at Pfam and SMART domain databases.
Mammalian FKBP25 possess exon-intron conservation, although conservation in the whole vertebrate lineage is incomplete.
The result of this study suggests that the purifying selection triggers FKBP25 evolutionary history, which allows us to discover the complete role of the PPIase domain in the interaction between FKBP25 and nuclear proteins.
Moreover, intron alterations during FKBP25 evolution that regulate gene splicing may be involved in the purifying selection.
American Psychological Association (APA)
Liu, Fei& Wei, Xiao-Long& Li, Hao& Wei, Ji-Fu& Wang, Yong-Qing& Gong, Xiao-Jian. 2014. Molecular Evolution of the Vertebrate FK506 Binding Protein 25. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469217
Modern Language Association (MLA)
Liu, Fei…[et al.]. Molecular Evolution of the Vertebrate FK506 Binding Protein 25. International Journal of Genomics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469217
American Medical Association (AMA)
Liu, Fei& Wei, Xiao-Long& Li, Hao& Wei, Ji-Fu& Wang, Yong-Qing& Gong, Xiao-Jian. Molecular Evolution of the Vertebrate FK506 Binding Protein 25. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469217