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Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering MonocytesMacrophages
Joint Authors
Karlsson Ott, Marjam
Santin, Matteo
Ferraz, Natalia
Hong, Jaan
Source
International Journal of Biomaterials
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study shows that alumina nanotopography affects monocyte/macrophage behavior.
Human mononuclear cells cultured on alumina membranes with pore diameters of 20 and 200 nm were evaluated in terms of cell adhesion, viability, morphology, and release of proinflammatory cytokines.
After 24 hours, cell adhesion was assessed by means of light microscopy and cell viability by measuring LDH release.
The inflammatory response was evaluated by quantifying interleukin-1β and tumour necrosis factor-α.
Finally, scanning electron microscopy was used to study cell morphology.
Results showed pronounced differences in cell number, morphology, and cytokine release depending on the nanoporosity.
Few but highly activated cells were found on the 200 nm porous alumina, while relatively larger number of cells were found on the 20 nm porous surface.
However, despite their larger number, the cells adhering on the 20 nm surface exhibited reduced pro-inflammatory activity.
The data of this paper implies that nanotopography could be exploited for controlling the inflammatory response to implants.
American Psychological Association (APA)
Ferraz, Natalia& Hong, Jaan& Santin, Matteo& Karlsson Ott, Marjam. 2010. Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering MonocytesMacrophages. International Journal of Biomaterials،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-469229
Modern Language Association (MLA)
Ferraz, Natalia…[et al.]. Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering MonocytesMacrophages. International Journal of Biomaterials No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-469229
American Medical Association (AMA)
Ferraz, Natalia& Hong, Jaan& Santin, Matteo& Karlsson Ott, Marjam. Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering MonocytesMacrophages. International Journal of Biomaterials. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-469229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469229