Novel LC Method Development and Validation for Simultaneous Determination of Montelukast and Doxofylline in Bulk and Pharmaceutical Dosage Forms
Joint Authors
Siva Kumar, A.
Nirupa, Gadapa
Tripathi, Upendra M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A novel rapid HPLC method was developed for simultaneous determination of montelukast and doxofylline in bulk and pharmaceutical dosage forms.
Development of an analytical method for simultaneous estimation of drugs requires a lot of efforts and of course it is a challenging task.
The method was developed by using C18 (150 mm×4.6 mm, 5 μm) column; mobile phase consisting of methanol and phosphate buffer at pH 4.5; the flow rate of 1.0 mL/min and ultraviolet detection at 280 nm.
Both drugs were sufficiently resolved having retention time of 4.7 min and 1.9 min for montelukast and doxofylline, respectively.
The method was validated as per ICH Guidelines for various parameters like precision, linearity, accuracy, ruggedness, and robustness.
The validated method was applied to the commercially available pharmaceutical dosage form and obtained the desired result.
American Psychological Association (APA)
Nirupa, Gadapa& Siva Kumar, A.& Tripathi, Upendra M.. 2012. Novel LC Method Development and Validation for Simultaneous Determination of Montelukast and Doxofylline in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469230
Modern Language Association (MLA)
Nirupa, Gadapa…[et al.]. Novel LC Method Development and Validation for Simultaneous Determination of Montelukast and Doxofylline in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469230
American Medical Association (AMA)
Nirupa, Gadapa& Siva Kumar, A.& Tripathi, Upendra M.. Novel LC Method Development and Validation for Simultaneous Determination of Montelukast and Doxofylline in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469230