Complement Activation : An Emerging Player in the Pathogenesis of Cardiovascular Disease
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
A wealth of evidence indicates a fundamental role for inflammation in the pathogenesis of cardiovascular disease (CVD), contributing to the development and progression of atherosclerotic lesion formation, plaque rupture, and thrombosis.
An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis.
Prospective and case control studies have reported strong relationships between several complement components and cardiovascular outcomes, and in vitro studies and animal models support a functional effect.
Complement activation, in particular, generation of C5a and C5b-9, influences many processes involved in the development and progression of atherosclerosis, including promotion of endothelial cell activation, leukocyte infiltration into the extracellular matrix, stimulation of cytokine release from vascular smooth muscle cells, and promotion of plaque rupture.
Complement activation also influences thrombosis, involving components of the mannose-binding lectin pathway, and C5b-9 in particular, through activation of platelets, promotion of fibrin formation, and impairment of fibrinolysis.
The participation of the complement system in inflammation and thrombosis is consistent with the physiological role of the complement system as a rapid effector system conferring protection following vessel injury.
However, in the context of CVD, these same processes contribute to development of atherosclerosis, plaque rupture, and thrombosis.
American Psychological Association (APA)
Carter, Angela M.. 2012. Complement Activation : An Emerging Player in the Pathogenesis of Cardiovascular Disease. Scientifica،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469237
Modern Language Association (MLA)
Carter, Angela M.. Complement Activation : An Emerging Player in the Pathogenesis of Cardiovascular Disease. Scientifica No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-469237
American Medical Association (AMA)
Carter, Angela M.. Complement Activation : An Emerging Player in the Pathogenesis of Cardiovascular Disease. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469237