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Mechanism of Anesthetic Toxicity : Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer
Joint Authors
Kovacic, Peter
Somanathan, Ratnasamy
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There is much literature on the toxic effects of anesthetics.
This paper deals with both the volatiles and locals.
Adverse effects appear to be multifaceted, with the focus on radicals, oxidative stress (OS), and electron transfer (ET).
ET functionalities involved are quinone, iminoquinone, conjugated iminium, and nitrone.
The non-ET routes involving radicals and OS apparently pertain to haloalkanes and ethers.
Beneficial effects of antioxidants, evidently countering OS, are reported.
Knowledge at the molecular level should aid in devising strategies to combat the adverse effects.
American Psychological Association (APA)
Kovacic, Peter& Somanathan, Ratnasamy. 2012. Mechanism of Anesthetic Toxicity : Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer. ISRN Anesthesiology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469246
Modern Language Association (MLA)
Kovacic, Peter& Somanathan, Ratnasamy. Mechanism of Anesthetic Toxicity : Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer. ISRN Anesthesiology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-469246
American Medical Association (AMA)
Kovacic, Peter& Somanathan, Ratnasamy. Mechanism of Anesthetic Toxicity : Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer. ISRN Anesthesiology. 2012. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469246