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Unraveling the Determinants of Protrusion Formation
Joint Authors
Gorsevski, Peter
Boudreau, Nancy S.
Varghese, Mita
Cayer, Marilyn L.
Heckman, Carol A.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A computerized morphometric classification technique based on latent factors reveals major protrusion classes: factors 4, 5, and 7.
Previous work showed that factor 4 represented filopodia, 5 the distribution of lamellar cytoplasm, and 7 a blunt protrusion.
We explore the relationship of focal contact (FC) characteristics and their integrated actin cables to factors values.
The results show that FC maturation/cytoskeletal integration affects factor 5, because FC elongation/integration was correlated with its values.
On the contrary, 7 values decreased with maturation, so cable or FC size or their integration must be restricted to form these protrusions.
Where integration did occur, the cables showed distinctive size and orientation, as indicated by correlation of 7 values with FC shape.
Results obtained with myosin inhibitors support the interpretation that a central, isometric, contractile network puts constraints on both factor 5 and 7 protrusions.
We conclude that cells establish functional domains by rearranging the cytoskeleton.
American Psychological Association (APA)
Varghese, Mita& Gorsevski, Peter& Cayer, Marilyn L.& Boudreau, Nancy S.& Heckman, Carol A.. 2012. Unraveling the Determinants of Protrusion Formation. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469247
Modern Language Association (MLA)
Varghese, Mita…[et al.]. Unraveling the Determinants of Protrusion Formation. International Journal of Cell Biology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-469247
American Medical Association (AMA)
Varghese, Mita& Gorsevski, Peter& Cayer, Marilyn L.& Boudreau, Nancy S.& Heckman, Carol A.. Unraveling the Determinants of Protrusion Formation. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469247