Flaxseed Ingestion Alters Ratio of Enterolactone Enantiomers in Human Serum
Joint Authors
Saarinen, Niina M.
Peñalvo, José L.
Mäkelä, Sari
Smeds, Annika I.
Adlercreutz, Herman
Nurmi, Tarja
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Enterolactone (EL) is an enterolignan found in human subjects.
In this pilot study, the enantiomeric ratios of serum EL were determined in serum from healthy adults during consumption of habitual diet, and after an 8-day supplementation with flaxseed (25 g/day).
(−)EL dominated in all serum samples collected during habitual diet consumption.
However, the ratio of (−)EL and (+)EL enantiomers differed markedly between individuals.
Flaxseed ingestion increased significantly the proportion of (+)EL in all subjects.
Moreover, a small but significant increase in serum (−)EL concentration was measured.
After flaxseed ingestion, (−)EL concentrations correlated with those of (+)EL suggesting that the stereochemistry of the parent plant lignan in flaxseed is not a major determinant of EL formation in human subjects.
Comparison of EL concentrations obtained with the validated chromatographic methods (HPLC-MS/MS, HPLC-CEAD, and GC-MS) and the time-resolved fluoroimmunoassay (TR-FIA) revealed that the immunoassay method underestimates human serum EL concentrations after the flaxseed ingestion.
American Psychological Association (APA)
Saarinen, Niina M.& Smeds, Annika I.& Peñalvo, José L.& Nurmi, Tarja& Adlercreutz, Herman& Mäkelä, Sari. 2010. Flaxseed Ingestion Alters Ratio of Enterolactone Enantiomers in Human Serum. Journal of Nutrition and Metabolism،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-469259
Modern Language Association (MLA)
Saarinen, Niina M.…[et al.]. Flaxseed Ingestion Alters Ratio of Enterolactone Enantiomers in Human Serum. Journal of Nutrition and Metabolism No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-469259
American Medical Association (AMA)
Saarinen, Niina M.& Smeds, Annika I.& Peñalvo, José L.& Nurmi, Tarja& Adlercreutz, Herman& Mäkelä, Sari. Flaxseed Ingestion Alters Ratio of Enterolactone Enantiomers in Human Serum. Journal of Nutrition and Metabolism. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-469259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469259