Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma : A Review and a Perspective
Joint Authors
Scholl, Susy M. E.
Kenter, Gemma
Beuzeboc, Philippe
Kurzeder, Christian
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Multiple genetic abnormalities will have occurred in advanced cervical cancer and multiple targeting is likely to be needed to control tumor growth.
To date, dominant therapeutic targets under scrutiny for cervical cancer treatment have been EGFR pathway and angiogenesis inhibition as well as anti-HPV vaccines.
The potentially most effective targets to be blocked may be downstream from the membrane receptor or at the level of the nucleus.
Alterations of the pathways involved in DNA repair and in checkpoint activations, as well as the specific site of HPV genome integration, appear worth assessing.
For genetic mutational analysis, complete exon sequencing may become the norm in the future but at this stage frequent mutations (that matter) can be verified by PCR analysis.
A precise documentation of relevant alterations of a large spectrum of protein biomarkers can be carried out by reverse phase protein array (RPPA) or by multiplex analysis.
Clinical decision-making on the drug(s) of choice as a function of the biological alteration will need input from bio-informatics platforms as well as novel statistical designs.
Endpoints are yet to be defined such as the loss (or reappearance) of a predictive biomarker.
Single or dual targeting needs to be explored first in relevant preclinical animal and in xenograft models prior to clinical deployment.
American Psychological Association (APA)
Scholl, Susy M. E.& Kenter, Gemma& Kurzeder, Christian& Beuzeboc, Philippe. 2011. Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma : A Review and a Perspective. ISRN Oncology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-469262
Modern Language Association (MLA)
Scholl, Susy M. E.…[et al.]. Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma : A Review and a Perspective. ISRN Oncology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-469262
American Medical Association (AMA)
Scholl, Susy M. E.& Kenter, Gemma& Kurzeder, Christian& Beuzeboc, Philippe. Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma : A Review and a Perspective. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-469262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469262