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Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis
Joint Authors
Bugli, Francesca
Cacaci, Margherita
Sanguinetti, Maurizio
Torelli, Riccardo
Martini, Cecilia
Paroni Sterbini, Francesco
Posteraro, Brunella
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Invasive candidiasis (IC) represents the leading fungal infection of humans causing life-threatening disease in immunosuppressed and neutropenic individuals including also the intensive care unit patients.
Despite progress in recent years in drugs development for the treatment of IC, morbidity and mortality rates still remain very high.
Historically, cell-mediated immunity and innate immunity are considered to be the most important lines of defense against candidiasis.
Nevertheless recent evidence demonstrates that antibodies with defined specificities could act with different degrees showing protection against systemic and mucosal candidiasis.
Mycograb is a human recombinant monoclonal antibody against heat shock protein 90 (Hsp90) that was revealed to have synergy when combined with fluconazole, caspofungin, and amphotericin B against a broad spectrum of Candida species.
Furthermore, recent studies have established an important role for Hsp90 in mediating Candida resistance to echinocandins, giving to this antibody molecule even more attractive biological properties.
In response to the failure of marketing authorization by the CHMP (Committee for Medicinal Products for Human Use) a new formulation of Mycograb, named Mycograb C28Y variant, with an amino acid substitution was developed in recent years.
First data on Mycograb C28Y variant indicate that this monoclonal antibody lacked efficacy in a murine candidiasis model.
American Psychological Association (APA)
Bugli, Francesca& Cacaci, Margherita& Martini, Cecilia& Torelli, Riccardo& Posteraro, Brunella& Sanguinetti, Maurizio…[et al.]. 2013. Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469265
Modern Language Association (MLA)
Bugli, Francesca…[et al.]. Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-469265
American Medical Association (AMA)
Bugli, Francesca& Cacaci, Margherita& Martini, Cecilia& Torelli, Riccardo& Posteraro, Brunella& Sanguinetti, Maurizio…[et al.]. Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469265