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Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults
Joint Authors
Bendix, Laila
Avlund, Kirsten
Osler, Merete
Kimura, Masayuki
Aviv, Abraham
Thinggaard, Mikael
Christensen, Kaare
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Introduction.
Fatigue is often present in older adults with no identified underlying cause.
The accruing burden of oxidative stress and inflammation might be underlying factors of fatigue.
We therefore hypothesized that leukocyte telomere length (LTL) is relatively short in older adults who experience fatigue.
Materials and Methods.
We assessed 439 older nondisabled Danish twins.
LTL was measured using Southern blots of terminal restriction fragments.
Fatigue was measured by the Mob-T Scale based on questions on whether the respondents felt fatigued after performing six mobility items.
Results.
LTL was significantly associated with fatigue (P=0.023), showing an increase of 0.038 kb/fatigue score unit.
Aging-related diseases and mental health did not explain the association, while lifestyle factors slightly attenuated the estimates.
Conclusion.
Our results support an association between LTL and fatigue.
Further studies are required to confirm this finding and the link of LTL with oxidative stress/inflammation over the life course.
American Psychological Association (APA)
Bendix, Laila& Thinggaard, Mikael& Kimura, Masayuki& Aviv, Abraham& Christensen, Kaare& Osler, Merete…[et al.]. 2014. Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults. Journal of Aging Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-469279
Modern Language Association (MLA)
Bendix, Laila…[et al.]. Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults. Journal of Aging Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-469279
American Medical Association (AMA)
Bendix, Laila& Thinggaard, Mikael& Kimura, Masayuki& Aviv, Abraham& Christensen, Kaare& Osler, Merete…[et al.]. Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults. Journal of Aging Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-469279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469279