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Animal Models of Chronic Pancreatitis
Joint Authors
Yamamoto, Mitsuyoshi
Yamaguchi, Taizo
Otsuki, Makoto
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models.
Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by intraductal infusion of oleic acid was persistent.
However, the destroyed acinar tissues were replaced by fatty tissues without fibrosis.
Transient stasis of pancreatic fluid flow by 0.01% agarose and minimum injury of the pancreatic duct by 0.1% NaTc solution induced progressive pancreatic injury although one alone is insufficient to cause persistent pancreatic injury.
However, the damaged tissue was replaced by fatty tissue without fibrosis.
Continuous pancreatic ductal hypertension (PDH) caused diffuse interlobular and intralobular fibrosis closely resembling human CP.
American Psychological Association (APA)
Otsuki, Makoto& Yamamoto, Mitsuyoshi& Yamaguchi, Taizo. 2010. Animal Models of Chronic Pancreatitis. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-469285
Modern Language Association (MLA)
Otsuki, Makoto…[et al.]. Animal Models of Chronic Pancreatitis. Gastroenterology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-469285
American Medical Association (AMA)
Otsuki, Makoto& Yamamoto, Mitsuyoshi& Yamaguchi, Taizo. Animal Models of Chronic Pancreatitis. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-469285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469285