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Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis
Joint Authors
Nguyen, Jacqueline
Meadow, Philip B.
Kesavarapu, Keerthana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Purpose.
To report a case of a patient with rheumatoid arthritis (RA) treated with tofacitinib citrate.
Methods.
Observational case report.
Results.
A 59-year-old patient, with a history of rheumatoid arthritis, on methotrexate 10 mg PO qwk and IV abatacept 750 mg/month, presented with photosensitivity, foreign body sensation, pain, redness, and blurry vision of her right eye (RE).
Visual acuity of the RE was 20/200 and 20/20 of the left eye (LE).
The slit lamp examination of the RE revealed dryness, 2+ injection of the conjunctiva, and pericentral ulceration of the cornea with 20–30% stromal thinning, pannus, and diffuse punctate epithelial erosions.
The anterior chamber appeared normal.
Laboratory values revealed elevated levels of rheumatoid factor, anticyclic citrullinated peptide antibodies, and C-reactive protein.
The patient was switched to tofacitinib citrate 5 mg PO b.i.d, underwent corneal gluing, and was given prednisone acetate 1% gt TID, polytrim gt TID, neomycin-polymyxin-dexameth gt QD, FreshKote lubricant 1.8% gt QID, moxifloxacin 0.5% gt QID, and preservative free artificial tears Q1H.
Within one week, laboratory values normalized, symptoms diminished, and the cornea reepithelialized.
Conclusion.
RA can present with ulcerative keratitis.
Tofacitinib citrate, steroids, and corneal gluing were found to halt the progression of keratolysis and promote reepithelialization.
American Psychological Association (APA)
Meadow, Philip B.& Nguyen, Jacqueline& Kesavarapu, Keerthana. 2014. Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis. Case Reports in Rheumatology،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-469288
Modern Language Association (MLA)
Meadow, Philip B.…[et al.]. Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis. Case Reports in Rheumatology No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-469288
American Medical Association (AMA)
Meadow, Philip B.& Nguyen, Jacqueline& Kesavarapu, Keerthana. Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis. Case Reports in Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-469288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469288