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Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
Joint Authors
Talib, Herni
Tie, Tung Hing
Basir, Rusliza
Chuah, Yaw Kuang
Nordin, Norshariza
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands.
RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules.
These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation.
RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis.
Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized.
In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions.
American Psychological Association (APA)
Chuah, Yaw Kuang& Basir, Rusliza& Talib, Herni& Tie, Tung Hing& Nordin, Norshariza. 2013. Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-469289
Modern Language Association (MLA)
Chuah, Yaw Kuang…[et al.]. Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. International Journal of Inflammation No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-469289
American Medical Association (AMA)
Chuah, Yaw Kuang& Basir, Rusliza& Talib, Herni& Tie, Tung Hing& Nordin, Norshariza. Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-469289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469289