Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa
Joint Authors
Żaba, Małgorzata
Kucharzewski, Marek
Sabat, Daniel
Domal-Kwiatkowska, Dorota
Wyrobiec, Grzegorz
Kurek, Józef
Helewski, Krzysztof
Stawski, Tomasz
Dudek, Damian
Liczko, Jacek
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We characterised a tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression in relation to severity of inflammatory infiltration of the gallbladder mucosa in a chronic cholecystitis.
We prospectively studied the gallbladder specimens obtained from 54 patients who had undergone cholecystectomy due to chronic calculous cholecystitis and 16 calculosis-free gallbladder specimens obtained from patients who underwent cholecystectomy due to the polyp/polyps as well as in cases of gallbladder injury.
To assess TF and TFPI immunoreactivity by immunohistochemistry, the monoclonal anti-human TF and TFPI antibodies were used.
The inflammatory infiltration of the gallbladder mucosa was reflected by the number of CD3 and CD68 positive cells.
The expression of TF and TFPI differed significantly between the cholecystitis and the control group.
Most capillary endothelial cells of the cholecystitis group presented weak expression for TFPI.
The mean number of CD3 positive lymphocytes in the cholecystitis group was 18.6 ± 12.2, but the mean number of CD68 positive cells was 29.7 ± 13.9.
In the control sections, it was 3.1 ± 1.9 and 8.8 ± 3.9, respectively (P<0.001).
The results of the current study suggest that the tissue procoagulant state found may be engaged in the etiopathogenesis of the cholecystitis.
American Psychological Association (APA)
Liczko, Jacek& Stawski, Tomasz& Żaba, Małgorzata& Kurek, Józef& Sabat, Daniel& Wyrobiec, Grzegorz…[et al.]. 2014. Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-469309
Modern Language Association (MLA)
Liczko, Jacek…[et al.]. Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-469309
American Medical Association (AMA)
Liczko, Jacek& Stawski, Tomasz& Żaba, Małgorzata& Kurek, Józef& Sabat, Daniel& Wyrobiec, Grzegorz…[et al.]. Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-469309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469309