Pain in Amyotrophic Lateral Sclerosis : A Neglected Aspect of Disease
Joint Authors
Handy, Chalonda R.
Federici, Thais
Krudy, Christina
Boulis, Nicholas
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor neurons, muscle wasting, and respiratory dysfunction.
With disease progression, secondary symptoms arise creating new problematic conditions for ALS patients.
Amongst these is pain.
Although not a primary consequence of disease, pain occurs in a substantial number of individuals.
Yet, studies investigating its pathomechanistic properties in the ALS patient are lacking.
Therefore, more exploratory efforts into its scope, severity, impact, and treatment should be initiated.
Several studies investigating the use of Clostridial neurotoxins for the reduction of pain in ALS patients suggest the potential for a neural specific approach involving focal drug delivery.
Gene therapy represents a way to accomplish this.
Therefore, the use of viral vectors to express transgenes that modulate the nociceptive cascade could prove to be an effective way to achieve meaningful benefit in conditions of pain in ALS.
American Psychological Association (APA)
Handy, Chalonda R.& Krudy, Christina& Boulis, Nicholas& Federici, Thais. 2011. Pain in Amyotrophic Lateral Sclerosis : A Neglected Aspect of Disease. Neurology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469324
Modern Language Association (MLA)
Handy, Chalonda R.…[et al.]. Pain in Amyotrophic Lateral Sclerosis : A Neglected Aspect of Disease. Neurology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-469324
American Medical Association (AMA)
Handy, Chalonda R.& Krudy, Christina& Boulis, Nicholas& Federici, Thais. Pain in Amyotrophic Lateral Sclerosis : A Neglected Aspect of Disease. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469324