![](/images/graphics-bg.png)
Molecular Pathology of Hepatic Neoplasms : Classification and Clinical Significance
Joint Authors
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Recent technological advances have enabled investigators to characterize the molecular genetics and genomics of hepatic neoplasia in remarkable detail.
From these studies, an increasing number of molecular markers are being identified that correlate with clinically important tumor phenotypes.
This paper discusses current knowledge relevant to the molecular classification of epithelial primary hepatic tumors that arise in adults, including focal nodular hyperplasia (FNH), hepatocellular adenoma (HCA), hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and combined HCC-CC.
Genetic analysis has defined molecular subtypes of HCA that are clinicopathologically distinct and can be distinguished through immunohistochemistry.
Gene expression studies have identified molecular signatures of progression from dysplastic nodules (DNs) to early HCC in cirrhosis.
Analyses of the mutational spectra, chromosomal aberrations and instability, transcriptomics, and microRNA profiles of HCC have revealed the existence of biologically distinct subtypes of this common malignancy, with prognostic implications.
Molecular characterization of biliary and hepatic progenitor cell phenotypes in liver cancer has shed new light on the histogenesis of these tumors and has focused attention on novel therapeutic targets.
In coming years, the molecular classification of hepatic neoplasms will be increasingly valuable for guiding patient care, as targeted therapies for liver cancer are developed and brought into clinical practice.
American Psychological Association (APA)
Walther, Zenta& Jain, Dhanpat. 2011. Molecular Pathology of Hepatic Neoplasms : Classification and Clinical Significance. Pathology Research International،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-469336
Modern Language Association (MLA)
Walther, Zenta& Jain, Dhanpat. Molecular Pathology of Hepatic Neoplasms : Classification and Clinical Significance. Pathology Research International No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-469336
American Medical Association (AMA)
Walther, Zenta& Jain, Dhanpat. Molecular Pathology of Hepatic Neoplasms : Classification and Clinical Significance. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-469336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469336