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Pathological Features of New Animal Models for Primary Biliary Cirrhosis
Joint Authors
Tsuneyama, Koichi
Kikuchi, Kentaro
Moritoki, Yuki
Nakanuma, Yasuni
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by immune mediated biliary damage and frequent appearance of autoantibodies against mitochondrial enzymes.
There is almost no useful animal model that is globally recognized and routinely used, however, several unique animal models manifested the characteristic clinical and pathological features of human PBC within the last 5 years.
Herein, we compare the pathological features of previously reported and newly introduced novel animal models of PBC.
Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising therapies and novel tools to characterize these clinical conditions.
Moreover, suitability of the model for the intended purpose should be confirmed by further research and analysis.
American Psychological Association (APA)
Tsuneyama, Koichi& Moritoki, Yuki& Kikuchi, Kentaro& Nakanuma, Yasuni. 2011. Pathological Features of New Animal Models for Primary Biliary Cirrhosis. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469338
Modern Language Association (MLA)
Tsuneyama, Koichi…[et al.]. Pathological Features of New Animal Models for Primary Biliary Cirrhosis. International Journal of Hepatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-469338
American Medical Association (AMA)
Tsuneyama, Koichi& Moritoki, Yuki& Kikuchi, Kentaro& Nakanuma, Yasuni. Pathological Features of New Animal Models for Primary Biliary Cirrhosis. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469338