The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia
Joint Authors
Si, Jianmin
Lu, Xiaofeng
Zhou, Qunyan
Chen, Shujie
Wang, Liangjing
Zhong, Jing
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα in vivo remain unclear.
We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium.
The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P<0.05), while the number of glands dramatically decreased (P<0.05).
In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II.
The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P<0.01).
Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P<0.05).
Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats.
American Psychological Association (APA)
Chen, Shujie& Zhong, Jing& Zhou, Qunyan& Lu, Xiaofeng& Wang, Liangjing& Si, Jianmin. 2011. The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469339
Modern Language Association (MLA)
Chen, Shujie…[et al.]. The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia. Gastroenterology Research and Practice No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-469339
American Medical Association (AMA)
Chen, Shujie& Zhong, Jing& Zhou, Qunyan& Lu, Xiaofeng& Wang, Liangjing& Si, Jianmin. The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469339
