Coexistence of Plasma Cell Dyscrasia with Prefibrotic Stage of Primary Myelofibrosis : A Case Report
Joint Authors
Stylianou, Konstantinos
Tsirakis, George
Alexandrakis, Michael G.
Passam, Andrew
Zampoulaki, Amalia
Kaparou, Maria
Kanellou, Peggy
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Coexistence of myeloproliferative neoplasms with lymphoproliferative syndromes has been described in the past, whereas plasma cell dyscrasias seem to be the most common cases.
Case Presentation.
We present a case of a 59-year-old Caucasian female of Greek origin who presented with thrombocytosis.
Clinical and laboratory investigation disclosed the presence of a smoldering myeloma with coexisting histological and molecular characteristics of primary myelofibrosis.
The patient had the acquired point mutation V617F in the JAK2 gene but not the bcr-abl rearrangement and was treated for myelofibrosis with subsequent improvement of all haematological parameters without evidence of myelomatic evolution.
Conclusion.
We present the first case in the literature of a smoldering myeloma coexisting with primary myelofibrosis.
The underlying pathogenetic mechanism could be either related to the presence of a pluripotent neoplastic stem cell capable to differentiate into both lymphoid and myeloid cells or be related to two separate nosologic entities.
American Psychological Association (APA)
Tsirakis, George& Kanellou, Peggy& Kaparou, Maria& Passam, Andrew& Zampoulaki, Amalia& Stylianou, Konstantinos…[et al.]. 2011. Coexistence of Plasma Cell Dyscrasia with Prefibrotic Stage of Primary Myelofibrosis : A Case Report. ISRN Hematology،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-469346
Modern Language Association (MLA)
Tsirakis, George…[et al.]. Coexistence of Plasma Cell Dyscrasia with Prefibrotic Stage of Primary Myelofibrosis : A Case Report. ISRN Hematology No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-469346
American Medical Association (AMA)
Tsirakis, George& Kanellou, Peggy& Kaparou, Maria& Passam, Andrew& Zampoulaki, Amalia& Stylianou, Konstantinos…[et al.]. Coexistence of Plasma Cell Dyscrasia with Prefibrotic Stage of Primary Myelofibrosis : A Case Report. ISRN Hematology. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-469346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469346