Juvenile Myasthenia Gravis : A Paediatric Perspective
Joint Authors
Finnis, Maria F.
Jayawant, Sandeep
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Myasthenia gravis (MG) is an autoimmune disease in which antibodies are directed against the postsynaptic membrane of the neuromuscular junction, resulting in muscle weakness and fatigability.
Juvenile myasthenia gravis (JMG) is a rare condition of childhood and has many clinical features that are distinct from adult MG.
Prepubertal children in particular have a higher prevalence of isolated ocular symptoms, lower frequency of acetylcholine receptor antibodies, and a higher probability of achieving remission.
Diagnosis in young children can be complicated by the need to differentiate from congenital myasthenic syndromes, which do not have an autoimmune basis.
Treatment commonly includes anticholinesterases, corticosteroids with or without steroid-sparing agents, and newer immune modulating agents.
Plasma exchange and intravenous immunoglobulin (IVIG) are effective in preparation for surgery and in treatment of myasthenic crisis.
Thymectomy increases remission rates.
Diagnosis and management of children with JMG should take account of their developmental needs, natural history of the condition, and side-effect profiles of treatment options.
American Psychological Association (APA)
Finnis, Maria F.& Jayawant, Sandeep. 2011. Juvenile Myasthenia Gravis : A Paediatric Perspective. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469351
Modern Language Association (MLA)
Finnis, Maria F.& Jayawant, Sandeep. Juvenile Myasthenia Gravis : A Paediatric Perspective. Autoimmune Diseases No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-469351
American Medical Association (AMA)
Finnis, Maria F.& Jayawant, Sandeep. Juvenile Myasthenia Gravis : A Paediatric Perspective. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469351