Mood Predicts Response to Placebo CPAP
Joint Authors
Loredo, José S.
Bardwell, Wayne A.
Mao, Wei-Chung
Stepnowsky, Carl J.
Dimsdale, Joel E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Study Objectives.
Continuous positive airway pressure (CPAP) therapy is efficacious for treating obstructive sleep apnea (OSA), but recent studies with placebo CPAP (CPAP administered at subtherapeutic pressure) have revealed nonspecific (or placebo) responses to CPAP treatment.
This study examined baseline psychological factors associated with beneficial effects from placebo CPAP treatment.
Participants.
Twenty-five participants were studied with polysomnography at baseline and after treatment with placebo CPAP.
Design.
Participants were randomized to either CPAP treatment or placebo CPAP.
Baseline mood was assessed with the Profile of Mood States (POMS).
Total mood disturbance (POMS-Total) was obtained by summing the six POMS subscale scores, with Vigor weighted negatively.
The dependent variable was changed in apnea-hypopnea index (ΔAHI), calculated by subtracting pre- from post-CPAP AHI.
Negative values implied improvement.
Hierarchical regression analysis was performed, with pre-CPAP AHI added as a covariate to control for baseline OSA severity.
Results.
Baseline emotional distress predicted the drop in AHI in response to placebo CPAP.
Highly distressed patients showed greater placebo response, with a 34% drop (i.e., improvement) in AHI.
Conclusion.
These findings underscore the importance of placebo-controlled studies of CPAP treatment.
Whereas such trials are routinely included in drug trials, this paper argues for their importance even in mechanical-oriented sleep interventions.
American Psychological Association (APA)
Stepnowsky, Carl J.& Mao, Wei-Chung& Bardwell, Wayne A.& Loredo, José S.& Dimsdale, Joel E.. 2012. Mood Predicts Response to Placebo CPAP. Sleep Disorders،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-469361
Modern Language Association (MLA)
Stepnowsky, Carl J.…[et al.]. Mood Predicts Response to Placebo CPAP. Sleep Disorders No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-469361
American Medical Association (AMA)
Stepnowsky, Carl J.& Mao, Wei-Chung& Bardwell, Wayne A.& Loredo, José S.& Dimsdale, Joel E.. Mood Predicts Response to Placebo CPAP. Sleep Disorders. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-469361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469361