Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
Joint Authors
Lee, Jen-Chih
Lin, Ting-Hui
Tseng, Min-Jen
Shih, Chuen-Ming
Chen, Wei
Tsai, Kuen-Daw
Yang, Shu-Mei
Wong, Ho-Yiu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Panax notoginseng (PN) is a traditional Chinese herb experimentally proven to have anti-inflammatory effects, and it is used clinically for the treatment of atherosclerosis, cerebral infarction, and cerebral ischemia.
This study aimed to determine the anti-inflammatory effects of PN against bleomycin-induced pulmonary fibrosis in mice.
First, in an in vitro study, culture media containing lipopolysaccharide (LPS) was used to stimulate macrophage cells (RAW 264.7 cell line).
TNF-α and IL-6 levels were then determined before and after treatment with PN extract.
In an animal model (C57BL/6 mice), a single dose of PN (0.5 mg/kg) was administered orally on Day 2 or Day 7 postbleomycin treatment.
The results showed that TNF-α and IL-6 levels increased in the culture media of LPS-stimulated macrophage cells, and this effect was significantly inhibited in a concentration-dependent manner by PN extract.
Histopathologic examination revealed that PN administered on Day 7 postbleomycin treatment significantly decreased inflammatory cell infiltrates, fibrosis scores, and TNF-α, TGF-β, IL-1β, and IL-6 levels in bronchoalveolar lavage fluid when compared with PN given on Day 2 postbleomycin treatment.
These results suggest that PN administered in the early fibrotic stage can attenuate pulmonary fibrosis in an animal model of idiopathic pulmonary fibrosis.
American Psychological Association (APA)
Tsai, Kuen-Daw& Yang, Shu-Mei& Lee, Jen-Chih& Wong, Ho-Yiu& Shih, Chuen-Ming& Lin, Ting-Hui…[et al.]. 2011. Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469408
Modern Language Association (MLA)
Tsai, Kuen-Daw…[et al.]. Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-469408
American Medical Association (AMA)
Tsai, Kuen-Daw& Yang, Shu-Mei& Lee, Jen-Chih& Wong, Ho-Yiu& Shih, Chuen-Ming& Lin, Ting-Hui…[et al.]. Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469408