Pro-Inflammatory Cytokine-Mediated Anemia : Regarding Molecular Mechanisms of Erythropoiesis
Joint Authors
Morceau, Franck
Dicato, Mario
Diederich, Marc
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Anemia of cancer and chronic inflammatory diseases is a frequent complication affecting quality of life.
For cancer patients it represents a particularly bad prognostic.
Low level of erythropoietin is considered as one of the causes of anemia in these pathologies.
The deficiency in erythropoietin production results from pro-inflammatory cytokines effect.
However, few data is available concerning molecular mechanisms involved in cytokine-mediated anemia.
Some recent publications have demonstrated the direct effect of pro-inflammatory cytokines on cell differentiation towards erythroid pathway, without erythropoietin defect.
This suggested that pro-inflammatory cytokine-mediated signaling pathways affect erythropoietin activity.
They could interfere with erythropoietin-mediated signaling pathways, inducing early apoptosis and perturbing the expression and regulation of specific transcription factors involved in the control of erythroid differentiation.
In this review we summarize the effect of tumor necrosis factor (TNF)α, TNF-related apoptosis-inducing ligand (TRAIL), and interferon (IFN)-γ on erythropoiesis with a particular interest for molecular feature.
American Psychological Association (APA)
Morceau, Franck& Dicato, Mario& Diederich, Marc. 2010. Pro-Inflammatory Cytokine-Mediated Anemia : Regarding Molecular Mechanisms of Erythropoiesis. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-469428
Modern Language Association (MLA)
Morceau, Franck…[et al.]. Pro-Inflammatory Cytokine-Mediated Anemia : Regarding Molecular Mechanisms of Erythropoiesis. Mediators of Inflammation No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-469428
American Medical Association (AMA)
Morceau, Franck& Dicato, Mario& Diederich, Marc. Pro-Inflammatory Cytokine-Mediated Anemia : Regarding Molecular Mechanisms of Erythropoiesis. Mediators of Inflammation. 2010. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-469428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469428