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Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration
Joint Authors
Numakawa, Tadahiro
Numakawa, Yumiko
Kunugi, Hiroshi
Matsumoto, Tomoya
Richards, Misty
Yamawaki, Shigeto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Oxidative stress is involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Low levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important for maintenance of neuronal function, though elevated levels lead to neuronal cell death.
A complex series of events including excitotoxicity, Ca2+ overload, and mitochondrial dysfunction contributes to oxidative stress-mediated neurodegeneration.
As expected, many antioxidants like phytochemicals and vitamins are known to reduce oxidative toxicity.
Additionally, growing evidence indicates that neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and estrogens significantly prevent neuronal damage caused by oxidative stress.
Here, we review and discuss recent studies addressing the protective mechanisms of neurotrophic factors and estrogen within this system.
American Psychological Association (APA)
Numakawa, Tadahiro& Matsumoto, Tomoya& Numakawa, Yumiko& Richards, Misty& Yamawaki, Shigeto& Kunugi, Hiroshi. 2011. Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-469450
Modern Language Association (MLA)
Numakawa, Tadahiro…[et al.]. Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration. Journal of Toxicology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-469450
American Medical Association (AMA)
Numakawa, Tadahiro& Matsumoto, Tomoya& Numakawa, Yumiko& Richards, Misty& Yamawaki, Shigeto& Kunugi, Hiroshi. Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-469450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469450