Therapeutic Improvement of Scarring : Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments
Joint Authors
Burgoyne, Nicholas J.
Metcalfe, Anthony D.
Ferguson, Mark W. J.
Nield, Kerry
Boanas, Adam
Occleston, Nick L.
O'Kane, Sharon
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Scarring in the skin after trauma, surgery, burn or sports injury is a major medical problem, often resulting in loss of function, restriction of tissue movement and adverse psychological effects.
Whilst various studies have utilised a range of model systems that have increased our understanding of the pathways and processes underlying scar formation, they have typically not translated to the development of effective therapeutic approaches for scar management.
Existing treatments are unreliable and unpredictable and there are no prescription drugs for the prevention or treatment of dermal scarring.
As a consequence, scar improvement still remains an area of clear medical need.
Here we describe the basic science of scar-free and scar-forming healing, the utility of pre-clinical model systems, their translation to humans, and our pioneering approach to the discovery and development of therapeutic approaches for the prophylactic improvement of scarring in man
American Psychological Association (APA)
Occleston, Nick L.& Metcalfe, Anthony D.& Boanas, Adam& Burgoyne, Nicholas J.& Nield, Kerry& O'Kane, Sharon…[et al.]. 2010. Therapeutic Improvement of Scarring : Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-469456
Modern Language Association (MLA)
Occleston, Nick L.…[et al.]. Therapeutic Improvement of Scarring : Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments. Dermatology Research and Practice No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-469456
American Medical Association (AMA)
Occleston, Nick L.& Metcalfe, Anthony D.& Boanas, Adam& Burgoyne, Nicholas J.& Nield, Kerry& O'Kane, Sharon…[et al.]. Therapeutic Improvement of Scarring : Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-469456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469456