Virologic Outcome of Using TenofovirEmtricitabine to Treat Hepatitis B in HIV-Coinfected Patients
Joint Authors
Engell, Christian A.
Aberg, Judith A.
Pham, Vinh Philip
Holzman, Robert S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Goal.
To study the effect of combination antiviral therapy with tenofovir and emtricitabine or lamivudine with and without prior monotherapy with lamivudine.
Study.
We reviewed charts of 31 HIV-/HBV-coinfected patients.
Twelve 3TC-naïve patients initially received tenofovir plus emtricitabine.
Nineteen epivir experienced patients who had previously failed epivir were given tenofovir plus emtricitabine.
Results.
Baseline median HBV DNA was similar in the epivir-naïve (5.8×107 copies/mL) and experienced group (7.3×107 copies/mL, P = .65).
The median time to complete suppression of HBV was 466 days in the naïve group and 877 days in the experienced (P = .001).
After 12 months, 6/10 (60%) naïve patients and 3/14 (21%) experienced patients had HBV DNA below the detectionlimit (P = .067).
After 24 months, 5/5 (100%) naïve patients and 4/13 (31%) experienced patients had an undetectable HBV DNA level (P = .015).
Conclusions.
The median time to suppression of HBV DNA was significantly shorter among treatment naïve patients.
There was a significantly greater proportion of naïve patients with suppressed HBV DNA at 24 months.
Our results support using initial dual therapy in those with HIV/HBV coinfection.
American Psychological Association (APA)
Engell, Christian A.& Pham, Vinh Philip& Holzman, Robert S.& Aberg, Judith A.. 2011. Virologic Outcome of Using TenofovirEmtricitabine to Treat Hepatitis B in HIV-Coinfected Patients. ISRN Gastroenterology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469473
Modern Language Association (MLA)
Engell, Christian A.…[et al.]. Virologic Outcome of Using TenofovirEmtricitabine to Treat Hepatitis B in HIV-Coinfected Patients. ISRN Gastroenterology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-469473
American Medical Association (AMA)
Engell, Christian A.& Pham, Vinh Philip& Holzman, Robert S.& Aberg, Judith A.. Virologic Outcome of Using TenofovirEmtricitabine to Treat Hepatitis B in HIV-Coinfected Patients. ISRN Gastroenterology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469473